Listeria monocytogenes Triggers AIM2-Mediated Pyroptosis upon Infrequent Bacteriolysis in the Macrophage Cytosol
نویسندگان
چکیده
منابع مشابه
Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.
The inflammasome pathway functions to regulate caspase-1 activation in response to a broad range of stimuli. Caspase-1 activation is required for the maturation of the pivotal pro-inflammatory cytokines of the pro-IL-1beta family. In addition, caspase-1 activation leads to a certain type of cell death known as pyroptosis. Activation of the inflammasome has been shown to play a critical role in ...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2010
ISSN: 1931-3128
DOI: 10.1016/j.chom.2010.04.004